It received poor reviews, but earned her a nomination for Scream Queen at the 2007 Scream Awards.
which followed a group of scientists who discover an alien buried deep in the ice of Antarctica, realizing too late that it is still alive. Kate Lloyd, a character she based on her sister, a neurologist. as Lauren Stinger, "long-time girlfriend of Carter (Scott) and the rock in his increasingly chaotic life." Winstead's acting was singled out by the Washington Post: “Winstead brings surprising depth to a small role, in which she has little to do except wait for her boyfriend to grow up, or to at least let go of his cynicism about love.” Screen Rant critic Ben Kendrick wrote: “Mary Elizabeth Winstead and Jessica Alba also deliver in their contributions – though both of their characters are mainly designed to be mirrors for Carter to examine his own life and choices.” In 2012 Winstead and Topher Grace appeared in The Beauty Inside, an "interactive social film".
and saw Winstead snagging the Dallas International Film Festival Award for Best Actress. It was broken into six filmed episodes interspersed with interactive storytelling, all on Alex (the main character)'s Facebook timeline.
2007 saw Winstead appear in a pair of high-profile event films.
Quentin Tarantino cast her as a well-intentioned but vapid and naïve actress in Death Proof, his high-speed segment of the double–feature exploitation thriller Grindhouse.
In 2013 Winstead was given the title role in Alex of Venice, directed by Chris Messina and penned by Jessica Goldberg.