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Transdermal estrogen also tends not to elevate triglycerides (a type of fat in the blood) as much as estrogen taken by pill/injection, so it is recommended if you are at risk of heart disease or stroke.

There are different chemical formulations of estrogen.

For medical professionals who are involved in prescribing hormones or are looking after the health of someone who is taking hormones, there is a detailed set of guidelines for doctors and nurses available from the Transgender Health Program (see last page).

How Hormones Work Hormones are chemical messengers produced by one part of the body to tell cells in another part of the body how to function, when to grow, when to divide, and when to die.

Changing these levels will affect fat distribution, muscle mass, hair growth, and other features that are associated with sex and gender.

For MTFs this can help make the body 2 2 The binary terms “male”,“female”,“masculine”,“feminine”,“masculinizing”, and “feminizing” don’t accurately reflect the diversity of trans people’s bodies or identities.

Cyproterone (Androcur®) can be used, but risks include depression and liver enzyme elevation so spironolactone is generally preferred.